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KMID : 1188320130070050576
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Gut and Liver
2013 Volume.7 No. 5 p.576 ~ p.584
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What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study
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Yusuke Kawamura
Kenji Ikeda
Taito Fukushima
Yuya Seko
Tasuku Hara
Hitomi Sezaki
Tetsuya Hosaka
Norio Akuta
Masahiro Kobayashi
Satoshi Saitoh
Fumitaka Suzuki
Yoshiyuki Suzuki
Yasuji Arase
Hiromitsu Kumada
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Abstract
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Background/Aims:The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion therapy for hepatocellular carcinoma (HCC).
Methods:We divided 13 HCC patients into the following three groups: group A, lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gelatin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes.
Results:The mean free cisplatin concentrations were as follows. For group A, the mean was 48.58 μg/mL at 0 minute, 7.31 μg/mL at 5 minutes, 5.70 μg/mL at 10 minutes, and 7.15 μg/mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65 μg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 μg/mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27 in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C.
Conclusions:These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver.
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KEYWORD
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Cisplatin, Attention, Carcinoma, hepatocellular, Drug delivery
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